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Focal nerve injury: Guidance factors during axonal regeneration
Author(s) -
Thomas P. K.
Publication year - 1989
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880121003
Subject(s) - regeneration (biology) , neuroscience , neurite , peripheral nerve , nerve injury , neurotrophic factors , peripheral nerve injury , extracellular matrix , axon , medicine , neurotrophin , nerve growth factor , anatomy , biology , microbiology and biotechnology , biochemistry , receptor , in vitro
Regeneration of axons after nerve injury is not random but is often not precise, particularly after injuries that involve nerve transection. The factors that guide regenerating axons toward appropriate terminations are complex, but developments in neurobiology are beginning to indicate the mechanisms that are involved. These include neurotrophic and neurite promoting factors, chemotactic influences from peripheral tissues, and the properties of the extracellular matrix. Understanding these mechanisms may indicate means of improving functional recovery after nerve injury.