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Differential effects of nerve, muscle, and fat tissue on regenerating nerve fibers in vivo
Author(s) -
Weis Joachim,
Schröder J. Michael
Publication year - 1989
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880120905
Subject(s) - connective tissue , regeneration (biology) , anatomy , neurotrophin , muscle tissue , epineurial repair , adipose tissue , in vivo , nerve fiber , chemistry , biology , pathology , medicine , microbiology and biotechnology , endocrinology , receptor
Axonal regeneration through silicone tubes was studied using distal nerve stumps, denervated, preatrophied muscle tissue, as well as fat tissue as a target. During the first stage of regeneration, i.e., within 2–3 weeks after surgery, a thin, filamentous structure consisting of fibrin and connective tissue‐was seen bridging the gap in all systems. Thereafter, this cord obviously served as a guideline for the outgrowth of increasing numbers of axons into distal nerve stumps as well as into muscle tissue, but not into fat tissue. These findings confirm that preatrophied muscle tissue has a similar “neurotrophic” effect on regenerating nerve fibers as distal nerve stumps. The ineffectivity of fat tissue in promoting nerve fiber regeneration could be attributed either to the absence of “neurotrophic factors” or even to an inhibitory effect.