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Localization of dystrophin in cultures of human muscle
Author(s) -
EcobPrince Marion S.,
Hill Mark A.,
Brown Aileen E.
Publication year - 1989
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880120711
Subject(s) - dystrophin , duchenne muscular dystrophy , myocyte , muscular dystrophy , itga7 , human muscle , medicine , biology , anatomy , microbiology and biotechnology , skeletal muscle
Dystrophin is a protein present in normal human muscle but absent in patients with Duchenne muscular dystrophy (DMD). Using a specific antibody, we have investigated the expression of dystrophin in human muscle which had regenerated in culture in the presence of nerve cells. Dystrophin was present and was correctly localized in the cultures of normal muscle but was absent from cultures of muscle from patients with DMD. Its control and function can now be studied.