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Asymptomatic hyper‐CK‐emia: An electrophysiologic and histopathologic study
Author(s) -
Joy Juan L.,
Oh Shin J.
Publication year - 1989
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880120308
Subject(s) - medicine , myopathy , muscle biopsy , asymptomatic , central core disease , mitochondrial myopathy , polymyositis , electromyography , pathology , biopsy , creatine kinase , gastroenterology , biochemistry , chemistry , ryanodine receptor , psychiatry , mitochondrial dna , gene , calcium , ryr1
Since the popularization of routine creatine kinase (CK) measurement, an increasing number of patients with unexplained CK elevation (“asymptomatic hyper‐CK‐emia”) are being identified. We studied 19 patients with persistent CK elevation of unknown etiology with electromyography (EMG) and muscle biopsy. Needle EMG was abnormal in 14 patients. Muscle biopsy was positive in all individuals with abnormal EMG and in one patient with normal EMG. Diagnoses included polymyositis in five patients, morphologically nonspecific myopathy in three, mitochondrial myopathy in two, and sarcoid myopathy, central core disease, multicore disease, inclusion body myopathy, and McArdle's disease in one case, respectively. Five patients with abnormal biopsies developed weakness within 1 year of presentation. We conclude that persistent asymptomatic CK elevation represents mild or early myopathy in a majority of cases.