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Central core disease: Ultrastructure of the sarcoplasmic reticulum and T‐tubules
Author(s) -
Hayashi Kazuko,
Miller Rodman G.,
Brownell A. Keith W.
Publication year - 1989
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880120203
Subject(s) - endoplasmic reticulum , central core disease , ultrastructure , golgi apparatus , anatomy , pathology , organelle , pathological , biology , medicine , microbiology and biotechnology , ryanodine receptor , ryr1
The modified Golgi staining method was used to study the sarcoplasmic reticulum (SR) and t‐ tubules of skeletal muscle in central core disease. Significant pathological changes were documented in both of these organelles in seven patients. Pathological changes were seen in both core and non‐core regions, with the abnormalities being greatest in the cores. In noncore regions, distortions in the normal anatomy were minor. In cores, there was much more significant distortion of the normal anatomy and also an increase in the amount of SR and number of t‐tubules.