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Effects of chronic prednisolone treatment on post junctional membrane responses to agonist
Author(s) -
Ribera Angeles B.,
Nastuk William L.
Publication year - 1988
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880110312
Subject(s) - prednisolone , agonist , medicine , endocrinology , chemistry , receptor
Using frogs treated 1 month with prednisolone, we studied responses of the muscle postjunctional membrane to acetylcholine and carbamylcholine. In control muscles following a bath application of 3 μ M neostigmine or 30 μ M pyridostigmine, there was an increased depolarization response to iontophoretically applied acetylcholine or carbamylcholine. Results with prednisolone‐treated frog muscle were essentially identical. In some fibers of prednisolone‐treated muscle there was a decrementing response to repetitive iontophoretic application of carbamylcholine. Prolonged administration of prednisolone may accelerate desensitization of acetylcholine receptors during repetitive application of agonist.