Chloroquine myopathy and myasthenia‐like syndrome | Zendy

Sghirlanzoni Angelo | Zendy; Mantegazza Renato | Zendy; Mora Marina | Zendy; Pareyson Davide | Zendy; Cornelio Ferdinando | Zendy

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Chloroquine myopathy and myasthenia‐like syndrome

Author(s) -

Sghirlanzoni Angelo,

Mantegazza Renato,

Mora Marina,

Pareyson Davide,

Cornelio Ferdinando

Publication year - 1988

Publication title -

muscle and nerve

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.025

H-Index - 145

eISSN - 1097-4598

pISSN - 0148-639X

DOI - 10.1002/mus.880110205

Subject(s) - chloroquine , medicine , discontinuation , myasthenia gravis , myopathy , muscle biopsy , pathogenesis , dermatology , biopsy , immunology , malaria

A young woman on chronic corticosteroid treatment for systemic lupus erythematosus developed a myasthenia‐like syndrome 7 weeks after starting chloroquine therapy. Discontinuation of chloroquine allowed symptomatic and immunological remission within 6 months. Ocular symptoms reappeared following a second short course of chloroquine. A motor‐point biopsy revealed a vacuolar myopathy with membranous bodies in intramuscular nerves. We discuss the possible role of chloroquine in the pathogenesis of a myasthenia‐like syndrome.

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