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Protron spin‐lattice relaxation time of duchenne dystrophy skeletal muscle by magnetic resonance imaging
Author(s) -
Matsumura Kiichiro,
Nakano Imaharu,
Fukuda Nobuo,
Ikehira Hiroo,
Tateno Yukio,
Aoki Yoshiro
Publication year - 1988
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880110202
Subject(s) - duchenne muscular dystrophy , magnetic resonance imaging , medicine , dystrophy , nuclear magnetic resonance , anatomy , chemistry , pathology , radiology , physics
By means of proton MRI, the spin‐lattice relaxation times ( T 1 values) of pelvic and leg muscles were measured in Duchenne muscular dystrophy (DMD) patients and normal controls. The bound water fraction (BWF) was calculated from the T 1 value obtained. In normal children, the T 1 value decreased, and BWF increased with age. In DMD, the T 1 value rapidly decreased, from an abnormally high value in the early stages, with the progress of the disease. This reduction of the T 1 value in DMD was not the same for all muscles; it was most prominent in the gluteus maximus and least prominent in the sartorius and gracilis muscles. BWF was below normal in the early stages of DMD . It is suggested that both regenerating and degenerating muscle fibers, together with the increased muscle water content, cause the high T 1 value and low BWF in the early stages of DMD, whereas replacement of muscle by fat causes the decreased T 1 value in the advanced stages.