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Growth of skeletal muscle from patients with amyotrophic lateral sclerosis transplanted into nude mice
Author(s) -
Gulati Adarsh K.,
Rivner Michael H.,
Shamsnia Morteza,
Swift Thomas R.,
Sohal Gurkirpal S.
Publication year - 1988
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880110107
Subject(s) - amyotrophic lateral sclerosis , skeletal muscle , nude mouse , transplantation , regeneration (biology) , pathology , medicine , anatomy , in vivo , biology , disease , microbiology and biotechnology
We studied the fate of skeletal muscle obtained from patients with amyotrophic lateral sclerosis (ALS) after transplantation into immunodeficient nude mice. The transplanted muscle consistently survived in the nude mice without immunological rejection. The myofibers in these muscles underwent degeneration, followed by regeneration, maturation, and eventual functional innervation by the mouse motor neurons. The ability to grow diseased human muscle successfully over a prolonged period in nude mice offers an in vivo model to study the etiology of ALS and possibly of other neuromuscular disorders.