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Increased skeletal muscle acetylcholinesterase activity in porcine malignant hyperthermia
Author(s) -
Mickelson James R.,
Thatte Hemant S.,
Beaudry Terrrence M.,
Gallant Esther M.,
Louis Charles F.
Publication year - 1987
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880100808
Subject(s) - sarcolemma , acetylcholinesterase , aché , skeletal muscle , endocrinology , medicine , malignant hyperthermia , chemistry , enzyme , biology , biochemistry , anesthesia
The content and distribution of acetylcholinesterase (AChE) activity in the skeletal muscle disorder malignant hyperthermia (MH) was examined. The AChE activity of sarcolemma membranes isolated from MH‐susceptible (MHS) swine was increased twofold when compared with normal sarcolemma. The total AChE activity of muscle extracts was also doubled in MHS tissue; however, the relative distribution between low‐salt extractable (globular forms) and high‐salt extractable (asymmetric forms) AChE activities were similar in MHS and normal muscle. Our results suggest that, for as yet unexplained reasons, both the sarcolemmal and total AChE activity of skeletal muscle is increased in porcine MH.