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Distant effects of local injection of botulinum toxin
Author(s) -
Lange Dale J.,
Brin Mitchell F.,
Warner Carolyn L.,
Fahn Stanley,
Lovelace Robert E.
Publication year - 1987
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880100610
Subject(s) - botulinum toxin , extensor digitorum communis , dystonia , neuromuscular transmission , medicine , toxin , neuromuscular junction , anesthesia , neurotransmission , electromyography , neuroscience , physical medicine and rehabilitation , chemistry , biology , biochemistry , receptor , psychiatry
We studied five patients who received local injections of botulinum toxin for dystonic disorders to determine if there had been any distant effect on neuromuscular transmission. No patient developed weakness or abnormalities on routine electrophysiologic testing. In all patients who received more than 245 U of toxin, SFEMG in the extensor digitorum communis muscle, a muscle distant to all those injected, was abnormal. Fiber density was increased in the two patients who received the largest cumulative dose. Jitter was maximally increased at slow firing rates, confirming its presynaptic basis. Our results reveal that there is an effect on neuromuscular transmission in muscles distant to those injected with botulinum toxin for dystonia.