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Electrophysiologic evidence of severe distal nerve segment pathology in the guillain–barré syndrome
Author(s) -
Miller Robert G.,
Peterson Christina,
Rosenberg Neil L.
Publication year - 1987
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880100606
Subject(s) - guillain barre syndrome , medicine , pathophysiology , weakness , electrodiagnosis , sensory nerve , electrophysiology , anesthesia , sensory system , pathology , neuroscience , anatomy , pediatrics , psychology
We report the clinical and electrophysiologic findings in 4 patients with Guillain–Barré syndrome (GBS) who, within 48 hours of onset, progressed to flaccid quadriplegia. Evoked muscle action potentials were absent or prolonged in latency and markedly reduced in amplitude within 48 hours of onset of weakness at a time when sensory nerve studies were almost normal. We conclude that pathophysiologic abnormalities may be distal and severe in some patients with GBS and that there is a predilection for motor axons in GBS.