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Serum creatine kinase isoenzymes in duchenne muscular dystrophy determined by sensitive enzyme immunoassay methods
Author(s) -
Mokuno Kenji,
Riku Shigeo,
Sugimura Kimiya,
Takahashi Akira,
Kato Kanefusa,
Osugi Shigeki
Publication year - 1987
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880100513
Subject(s) - duchenne muscular dystrophy , creatine kinase , medicine , immunoassay , isozyme , muscular dystrophy , endocrinology , enzyme , skeletal muscle , myopathy , carbonic anhydrase , creatine , chemistry , biochemistry , immunology , antibody
Serum levels of creatine kinase (CK) isoenzymes (MM, MB, and BB) were measured by sensitive enzyme immunoassay (EIA) methods in 50 patients with Duchenne muscular dystrophy (DMD) and in 39 controls. MM, MB, and BB levels in DMD patients were higher than in controls, and these three levels decreased with advancing age of DMD patients. Serum MB levels showed a good correlation with serum levels of carbonic anhydrase III (CA‐III), but correlated poorly with electrocardiographic findings, suggesting that the main origin of serum MB in DMD is skeletal muscle rather than cardiac muscle.