Premium
Serotonin uptake in blood platelets of duchenne muscular dystrophy patients
Author(s) -
Arora Ramesh C.,
Meltzer Herbert Y.,
Kuncl Ralph W.,
Morgan Juliet,
Cohen Louis
Publication year - 1987
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880100413
Subject(s) - duchenne muscular dystrophy , platelet , serotonin , medicine , creatine kinase , endocrinology , ambulatory , significant difference , chemistry , receptor
Serotonin (5‐HT) uptake was studied in the blood platelets of 10 patients with Duchenne‐type muscular dystrophy (DMD) and 7 age‐matched controls. V max (maximum number of uptake sites) of platelet 5‐HT uptake in the DMD patients was significantly less than that of the normal controls. There was no difference in the affinity for 5‐HT ( K m ) between the two groups. There was a significant negative correlation between serum creatine kinase activity and K m of 5‐HT uptake in blood platelets of these patients. However, no correlation was found between K m or V max and ambulatory status of DMD.