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Calcium‐activated protease in hamster cardiomyopathy
Author(s) -
Spalla Milena,
Kuo Tuan H.,
Wiener Joseph
Publication year - 1987
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880100111
Subject(s) - hamster , protease , enzyme , calcium , mesocricetus , cardiomyopathy , biochemistry , medicine , endocrinology , biology , chemistry , heart failure
Abstract A high calcium‐requiring protease was purified from the hearts of myopathic hamsters. The biochemical properties of the enzyme were studied with [ 3 H]acetylcasein as substrate. Comparison of the enzyme from hamster and rat hearts indicated no species specificity. Increased levels of the enzyme were associated with the development of cardiac lesions in myopathic hamsters.