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Decreased water permeability of erythrocyte membranes in patients with duchenne muscular dystrophy
Author(s) -
Serbu Ana Maria,
Marian Alice,
Popescu Octavian,
Pop Victor I.,
Borza Victoria,
Benga Ileana,
Benga Gheorghe
Publication year - 1986
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880090308
Subject(s) - duchenne muscular dystrophy , membrane , erythrocyte membrane , permeability (electromagnetism) , chemistry , muscular dystrophy , dystrophin , medicine , membrane permeability , biophysics , endocrinology , biochemistry , biology
Abstract The water proton relaxation times of erythrocytes ( T ′ 2a ) from 15 Duchenne muscular dystrophy (DMD) patients and age‐matched controls have been determined by a pulse nuclear magnetic resonance technique. Statistically significant higher values of T ′ 2a were noted for the DMD erythrocytes, both in the presence or absence of p ‐chloromercuribenzene sulfonate, a potent inhibitor of water diffusion through erythrocyte membrane. As the values of T ′ 2a are inversely related to the water permeability, the results indicate a decreased permeability of erythrocyte membrane in DMD. The findings are discussed in relation to the molecular mechanisms of water diffusion across erythrocyte membrane and in regard to the general problem of membran abnormalities in DMD.