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Insulin binding in denervated muscle
Author(s) -
Donaldson Deirdre,
Evans Owen B.,
Harrison Robert W.
Publication year - 1986
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880090304
Subject(s) - denervation , insulin , medicine , endocrinology , atrophy , insulin receptor , receptor , muscle atrophy , biology , chemistry , insulin resistance
Insulin binding was measured in rat muscle following denervation. There was a 40% reduction in the number of high‐affinity insulin receptors, with no change in the insulin binding K d . Selected muscles showed a 40%–60% reduction in weight during this period. The down regulation in the number of insulin receptors may contribute to the mechanism of muscle atrophy following denervation.