Premium
Decreased parvalbumin contents in skeletal muscles of C57BL/6J(dy 2J /dy 2J ) dystrophic mice
Author(s) -
Klug Gary,
Reichmann Heinz,
Pette Dirk
Publication year - 1985
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880080706
Subject(s) - parvalbumin , dystrophy , medicine , endocrinology , muscular dystrophy , hindlimb , chemistry , anatomy , biology , pathology , neuroscience
Abstract Parvalbumin content is decreased by 40% in hindlimb muscles of adult (3.5 months) dystrophic mice when compared to normal mice of the same age. The concentration of parvalbumin in the dystrophic muscles resembles that of immature muscles of 4‐week‐old normal mice. The reduction may contribute to an elevation of sarcoplasmic free CA 2+ , which could stimulate various Ca 2+ ‐dependent processes related to the disease.