The free cytoplasmic Ca 2+  levels in duchenne muscular dystrophy lymphocytes | Zendy

Klip Amira | Zendy; Elder Brian | Zendy; RuizFunes Hugo P. | Zendy; Buchwald Manuel | Zendy; Grinstein Sergio | Zendy

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The free cytoplasmic Ca 2+ levels in duchenne muscular dystrophy lymphocytes

Author(s) -

Klip Amira,

Elder Brian,

RuizFunes Hugo P.,

Buchwald Manuel,

Grinstein Sergio

Publication year - 1985

Publication title -

muscle and nerve

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.025

H-Index - 145

eISSN - 1097-4598

pISSN - 0148-639X

DOI - 10.1002/mus.880080408

Subject(s) - duchenne muscular dystrophy , cytoplasm , lymphoblast , muscular dystrophy , microbiology and biotechnology , chemistry , peripheral blood , endocrinology , medicine , biology , biochemistry , cell culture , genetics

An increased cellular Ca 2+ content has been associated with Duchenne muscular dystrophy (DMD). However, estimates of the free cytoplasmic Ca 2+ concentration ([Ca 2+ ]i) in cells of DMD patients were not available. We compared the [Ca 2+ ]i levels of normal and DMD peripheral blood lymphocytes and Epstein‐Barr virus‐transformed lymphoblasts using the novel probe, quin 2, an internally trapped fluorescent indicator. The [Ca 2+ ]i levels of normal and DMD cells were not significantly different.

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