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Initiation of differentiation into skeletal muscle fiber types
Author(s) -
Dhoot Gurtej K.
Publication year - 1985
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880080407
Subject(s) - myofibril , gene isoform , muscle fibre , immunohistochemistry , myocyte , skeletal muscle , biology , fiber type , cellular differentiation , myosin , microbiology and biotechnology , anatomy , chemistry , endocrinology , biochemistry , immunology , gene
A monoclonal antibody directed against a slow isoform of a 100‐K myofibrillar protein has been used to study the differentiation of muscle fibers in the fast and slow muscles of the rat. Immunohistochemical studies have shown that initiation of differentiation into fast and slow muscle fibers occurs very early during development. The distribution pattern of cell types in different muscles is unique and is also determined very early during fetal muscle development. It is concluded that motor innervation is probably not essential to initiate differentiation into distinct muscle fiber types.