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Granular nuclear inclusion body disease: Fine structure of tibial muscle and sural nerve
Author(s) -
Schröder Johann Michael,
Krämer Klaus Günter,
Hopf Hanns Christian
Publication year - 1985
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880080110
Subject(s) - hyaline , sural nerve , pathognomonic , inclusion bodies , anatomy , pathology , muscle biopsy , biopsy , medicine , biology , disease , biochemistry , escherichia coli , gene
Fine granular (hyaline) intranuclear inclusion bodies were found in perivascular cells of a muscle and a sural nerve biopsy from a 32‐year‐old woman with slowly progressive motor disturbances. The hyaline nuclear inclusion bodies could be distinguished from other intranuclear hyaline inclusions by their granularity, the size of the granules (approximately 5–15 nm), and the positive iron staining reaction. They were not seen in muscle fibers or Schwann cells. Because of these apparently pathognomonic structural features the patient appears to present a condition that has not been described before.