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Clinical investigation in duchenne muscular dystrophy: IV. Double. Blind controlled trial of leucine
Author(s) -
Mendell Jerry R.,
Griggs Robert C.,
Moxley Richard T.,
Fenichel Gerald M.,
Brooke Michael H.,
Miller J. Philip,
Province Michael A.,
Dodson W. Edwin
Publication year - 1984
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880070704
Subject(s) - duchenne muscular dystrophy , placebo , medicine , joint contracture , therapeutic effect , leucine , contracture , double blind , clinical trial , muscular dystrophy , anesthesia , surgery , chemistry , pathology , amino acid , biochemistry , alternative medicine
Ninety‐six patients with Duchenne muscular dystrophy (DMD) were randomized and placed either on placebo or oral leucine at a dose of 0.2 g per kg per day. Patients were evaluated using a protocol that measured muscle strength, joint contracture, functional grade and activity, and pulmonary function tests. After 1 month there was a transient but significant difference in the strength of the two groups, the treated group being stronger than the placebo group. At 6 months there was also a transient difference in joint contracture measurements. Analysis of the data showed that the difference between the groups for both these measurements could not be ascribed to a therapeutic effect of leucine but rather to an unexpected drop in the placebo group. This was recognized only because the slope of deterioration for these functions had been well documented during the natural history phase of the study. These results indicate that oral leucine failed to produce a therapeutic response over a 1‐year double‐blind, controlled trial.