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Endoneurial ATPase activity in tangier disease and other peripheral neuropathies
Author(s) -
Sutherland Wayne H. F.,
Pollock Martin
Publication year - 1984
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880070606
Subject(s) - tangier disease , medicine , peripheral neuropathy , peripheral , endocrinology , chemistry , biochemistry , gene , diabetes mellitus , transporter , abca1
Endoneurial sodium, potassium adenosine triphosphatase (Na + , K + ‐ATPase) and Mg 2+ ‐ATPase activities were determined in routine sural nerve biopsies from patients being evaluated for peripheral neuropathy. A significant reduction of endoneurial Na + , K + ‐ATPase and Mg 2+ ‐ATPase activities was shown in six sural nerve biopsies from patients with Tangier disease complicated by mononeuopathy multiplex or progressive axonal neuropathy. Peripheral nerve ATPase activities did not correlate with myelinated or unmyelinated nerve fiber densities in these biopsies. Other peripheral neuronal disorders with reduced endoneurial Na + , K + ‐ATPase and Mg 2+ ‐ATPase activities included severe vasculitic neuropathy, diabetic neuropathy, tomaculous neuropathy, and motoneuron disease. Such reduced levels of ATPase activity in peripheral nerve may relate to altered endoneurial lipid metabolism and impaired axoplasmic flow.