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Regenerative capability of skeletal muscle in chicken muscular dystrophy
Author(s) -
aka Ikuya,
Fujita Takehisa,
Sugita Hideo
Publication year - 1984
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880070510
Subject(s) - muscular dystrophy , chemistry , regeneration (biology) , aché , acetylcholinesterase , dystrophy , nicotinamide adenine dinucleotide , skeletal muscle , anatomy , lactic dehydrogenase , enzyme , biochemistry , biology , medicine , microbiology and biotechnology , nad+ kinase , genetics
To examine the morphological sequence of regenerating fibers after myonecrosis in dystrophic muscles, 0.5 ml of 0.5% bupivacaine hydrochloride (BPVC) (Marcaine) solution, a local anesthetic with a cytotoxic effect on the muscle fibers, was injected directly into the dystrophic (line 413) and nondystrophic (line 412) posterior latissimus dorsi (PLD) muscles of young and adult chickens. Although the dystrophic muscles after BPVC injection showed a rapid recovery with a similar tempo to that of nondystrophic ones, they showed different morphological behavior in the early phase of regeneration, including marked variability in the size of fibers and in the intracytoplasmic enzyme activities of nicotinamide adenine dinucleotide, reduced‐tetrazolium reductase (NADHTR), acetylcholinesterase (AChE), and nonspecific esterase (NSE).