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Increased myofibrillar protein catabolism in duchenne muscular dystrophy measured by 3‐methylhistidine excretion in the urine
Author(s) -
Mussini Emilio,
Cornelio Ferdinando,
Colombo Laura,
de Ponte Gloria,
Giudici Giovanni,
Cotellessa Laura,
Marcucci Franca
Publication year - 1984
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880070508
Subject(s) - myofibril , duchenne muscular dystrophy , catabolism , urine , protein catabolism , medicine , endocrinology , muscular dystrophy , excretion , chemistry , metabolism , biochemistry , amino acid
Myofibrillar protein catabolic rate was calculated in 50 young patients with Duchenne muscular dystrophy from the amount of 3‐methylhistidine excreted in the urine, and was found to be about seven times that of a control series, expressed as the percentage of myofibrillar protein catabolized per day. This wastage of myofibrillar protein is a consequence of Duchenne muscular dystrophy and inhibition of protein degradation appears to be one possible approach in the treatment of this disease.