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Nerve regeneration in exogenous cerebral ganglioside‐treated rats
Author(s) -
Sebille Alain
Publication year - 1984
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880070404
Subject(s) - ganglioside , intraperitoneal injection , sciatic nerve , saline , regeneration (biology) , isometric exercise , anesthesia , lumbar , medicine , plantaris muscle , anatomy , chemistry , endocrinology , skeletal muscle , biology , biochemistry , soleus muscle , microbiology and biotechnology
Intraperitoneal injection of 50 mg/kg of exogenous cerebral gangliosides resulted in a statistically significant (23%) increase (compared with saline‐injected controls) in the tetanic isometric tension of the rat plantaris muscle 7 days after section of the fourth lumbar root (L4). In a second experiment, intraperitoneal‐injected exogenous gangliosides were found to have no effect on axonal regeneration following cryoinjury to the sciatic nerve. These results lead to the possibility of an early enhancement of muscular collateral sprouting in partially denervated muscles under an intraperitoneal‐injected ganglioside mixture treatment.