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Peripheral neuropathy in osteosclerotic myeloma: Clinical and electrodiagnostic improvement with chemotherapy
Author(s) -
Donofrio P. D.,
Albers J. W.,
Greenberg H. S.,
Mitchell B. S.
Publication year - 1984
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880070209
Subject(s) - medicine , polyneuropathy , prednisone , peripheral neuropathy , melphalan , multiple myeloma , chemotherapy , surgery , oncology , diabetes mellitus , endocrinology
A patient with a severe remote‐effect polyneuropathy and other paraneoplastic features of osteosclerotic myeloma improved dramatically with melphalan and prednisone treatment. Serial electrodiagnostic studies provided an objective means of following the response to therapy and documented the improvement. We believe this represents the first reported patient with multifocal osteosclerotic myeloma and a myelomatous polyneuropathy responding to melphalan and prednisone.