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The CO‐dispersion index for the measurement of fiber type distribution patterns
Author(s) -
Lester James M.,
Silber Dennis I.,
Cohen Michael H.,
Hirsch Robert P.,
Bradley Walter G.,
Brenner John F.
Publication year - 1983
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880060808
Subject(s) - dispersion (optics) , contingency table , fiber , fiber type , index of dispersion , measure (data warehouse) , skeletal muscle , index (typography) , distribution (mathematics) , materials science , biological system , statistics , mathematics , computer science , medicine , physics , biology , mathematical analysis , anatomy , data mining , optics , composite material , poisson regression , population , environmental health , world wide web
There is a need for a practical and statistically manageable quantitative index of fiber type co‐dispersion in skeletal muscle to allow investigation of the distribution of motor units in normal muscle and their rearrangement in pathological states. A new measure for this purpose, the Co‐Dispersion Index (CDI), is introduced. This measure is based on contingency table analysis of nearest‐neighbor relationships between muscle fibers. The CDI has a continuous range of values from −1 to +1, in which larger negative values indicate a greater tendency toward regular intermixing of fibers of different types, and larger positive values a greater segregation of fiber types. CDI evaluation overcomes the limitations of previously published quantitative methods for codispersion measurement and is well correlated with subjective human estimates of fiber type grouping.