Muscle pyruvate oxidation following denervation and reinnervation | Zendy

Evans Owen B. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Muscle pyruvate oxidation following denervation and reinnervation

Author(s) -

Evans Owen B.

Publication year - 1983

Publication title -

muscle and nerve

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.025

H-Index - 145

eISSN - 1097-4598

pISSN - 0148-639X

DOI - 10.1002/mus.880060804

Subject(s) - denervation , reinnervation , pyruvate decarboxylation , pyruvate dehydrogenase complex , lactate dehydrogenase , medicine , endocrinology , chemistry , soleus muscle , pyruvate dehydrogenase phosphatase , sciatic nerve , biochemistry , biology , enzyme , anatomy , skeletal muscle

Muscle pyruvate metabolism was studied in rats following sciatic nerve crush. Control studies showed high pyruvate dehydrogenase and lipoamide dehydrogenase enzyme activity in muscle with type 1 fiber predominance (soleus) and low activities in muscle with type 2 fiber predominance (extensor digitorum longus), whereas lactate dehydrogenase was much higher in the latter. Following denervation, both muscles showed a significant reduction in pyruvate dehydrogenase enzyme activity. During reinnervation, muscle with type 2 predominance developed significantly elevated pyruvate oxidation enzyme activities.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research