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Muscle pyruvate oxidation following denervation and reinnervation
Author(s) -
Evans Owen B.
Publication year - 1983
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880060804
Subject(s) - denervation , reinnervation , pyruvate decarboxylation , pyruvate dehydrogenase complex , lactate dehydrogenase , medicine , endocrinology , chemistry , soleus muscle , pyruvate dehydrogenase phosphatase , sciatic nerve , biochemistry , biology , enzyme , anatomy , skeletal muscle
Muscle pyruvate metabolism was studied in rats following sciatic nerve crush. Control studies showed high pyruvate dehydrogenase and lipoamide dehydrogenase enzyme activity in muscle with type 1 fiber predominance (soleus) and low activities in muscle with type 2 fiber predominance (extensor digitorum longus), whereas lactate dehydrogenase was much higher in the latter. Following denervation, both muscles showed a significant reduction in pyruvate dehydrogenase enzyme activity. During reinnervation, muscle with type 2 predominance developed significantly elevated pyruvate oxidation enzyme activities.