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Malignant hyperthermia and related neuromuscular diseases: Caffeine contracture of the skinned muscle fibers
Author(s) -
Takagi Akio,
Sunohara Nobuhiko,
Ishihara Tadayuki,
aka Ikuya,
Sugita Hideo
Publication year - 1983
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880060707
Subject(s) - malignant hyperthermia , caffeine , contracture , medicine , neuromuscular junction , muscle contraction , physical medicine and rehabilitation , anesthesia , anatomy , surgery , neuroscience , psychology
Using the skinned fiber preparation, the response to caffeine was studied on the skeletal muscle of malignant hyperthermia or other neuromuscular diseases. The sensitivity to caffeine was increased in the muscle of malignant hyperthermia. The sensitivity also was increased in Duchenne muscular dystrophy or asymptomatic patients with raised serum creatine kinase activity. Judging from the interaction between caffeine and the contractile system, the abnormal response originated from the sarcoplasmic reticulum in malignant hyperthermia. In Duchenne muscular dystrophy, the contractile system also might be involved in the increased sensitivity. Since the disease spectrum presenting abnormal responses is broad, it is suggested that muscle fibers become sensitive to caffeine when they are degenerating or regenerating.