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Neuropathy in the hypereosinophilic syndrome
Author(s) -
Dorfman Leslie J.,
Ransom Bruce R.,
Forno Lysia S.,
Kelts Alan
Publication year - 1983
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880060408
Subject(s) - medicine , mononeuropathy , hypereosinophilic syndrome , eosinophilia , peripheral neuropathy , atrophy , pathology , carpal tunnel syndrome , eosinophil , muscle atrophy , neurotoxicity , surgery , toxicity , endocrinology , asthma , diabetes mellitus
Peripheral nerve dysfunction was a prominent clinical feature in each of three patients with the hypereosinophilic syndrome (HES). The neuropathy, occurring at the onset of marked eosinophilia or at a time of its worsening, had a painful onset, evolved over 1–4 weeks, and affected both sensory and motor function. Electrodiagnostic studies demonstrated both multifocal and generalized nerve involvement, with the former predominating (multiple mononeuropathy). Nerve and muscle biopsies from two patients revealed severe axonal degeneration with neurogenic atrophy of muscle. The eosinophilia decreased dramatically with corticosteroid treatment and the neuropathy gradually improved, but all three patients manifested residual neurologic disability 17–22 months after onset. The neuropathy may be on an ischemic basis or may be related to neurotoxicity of eosinophil products.