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Experimental myasthenia: Lack of correlation between the autoantibody titer and the reduction of acetylcholine‐controlled ionic channels measured at functioning endplates
Author(s) -
Hohlfeld Reinhard,
Sterz Raimund,
Kalies Inge,
Wekerle Hartmut,
Peper Klaus
Publication year - 1983
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880060213
Subject(s) - myasthenia gravis , autoantibody , acetylcholine receptor , titer , acetylcholine , medicine , antibody titer , immunology , endocrinology , chemistry , antibody , receptor
Inbred rats with experimental autoimmune myasthenia gravis (EAMG) show no correlation between the serum autoantibody (Antiacetylcholine receptor antibody) concentration and the reduction of endplate acetylcholine‐controlled ionic channels, as measured by a novel electrophysiological technique termed quantitative ionophoresis . This has implications for attempts to explain the well‐documented lack of correlation between the autoantibody titer and the clinical severity of myasthenia gravis (MG).