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Muscle function in rheumatic disease patients treated with corticosteroids
Author(s) -
Rothstein Jules M.,
Delitto Anthony,
Sinacore David R.,
Rose Stephen J.
Publication year - 1983
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880060208
Subject(s) - medicine , muscle power , rheumatoid arthritis , dynamometer , physical therapy , muscle atrophy , corticosteroid , atrophy , physical medicine and rehabilitation , cardiology , engineering , aerospace engineering
Clinical and experimental data indicate that long‐term corticosteroid use leads to atrophy of the type 2 muscle fibers. The purpose of this study was to characterize and quantify the nature of muscle function in rheumatic disease patients who have been on long‐term corticosteroid therapy. Quadriceps function (i.e., peak torque and power) in 19 patients (11 with rheumatoid arthritis, five with systemic lupus erythematosis, and 3 other) and 11 age‐ and activity‐matched normal controls was measured with an isokinetic dynamometer (Cybex II), during four constant velocity movements. Power was significantly lower for the patients at all speeds. At the higher speeds the patients' deficit in power production increased as indicated by a difference in the slopes of power‐velocity regression lines. Measures of peak torque could not be consistently used to differentiate the groups. Patients with rheumatic diseases receiving corticosteroids have a decreased ability to generate muscle power. The method described allows for quantification of these deficits in a clinical setting.