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Segmental necrosis in tenotomized muscle fibers
Author(s) -
Baker James H.
Publication year - 1983
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880060106
Subject(s) - tenotomy , sarcomere , myofibril , anatomy , soleus muscle , degeneration (medical) , population , fiber , muscle fibre , tendon , chemistry , medicine , pathology , skeletal muscle , myocyte , environmental health , organic chemistry
A study of the soleus muscle of the rat along its entire length during the first week following tenotomy was undertaken. Within the first few days the affected fibers of the soleus underwent a complete morphological reorganization. Portions of fibers near the tendons were Invaded by and replaced with a large population of phagocytes. Previous studies have implied that the number of sarcomeres in series is reduced, but it has not been demonstrated from what portion of the fiber the sarcomeres are revoved. Sections of fibers taken from the mid‐belly region demonstrated a progressive degenerative process over the first few days. Myofibrils across the entire width of the affected fibers underwent dissolution and degeneration. Fibers with central core lesions could be found by the seventh day after tenotomy, however, at this stage the peripheral myofibrils were new, and the fibers had begun the regenerative process which continued until normal fiber histology was restored.