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Exercise effects on recovery of muscle acetylcholinesterase from reduced neuromuscular activity
Author(s) -
Gardiner Phillip F.,
Lapointe Mario,
Gravel Diane
Publication year - 1982
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880050505
Subject(s) - acetylcholinesterase , physical medicine and rehabilitation , neuromuscular junction , medicine , neuroscience , psychology , chemistry , biochemistry , enzyme
In order to investigate the effects of reduced and subsequently increased neuromuscular activity on muscle acetylcholinesterase (AChE), rats had one hindlimb immobilized with plaster casts for 4 weeks and were killed either at the end of immobilization (group I), after 4 weeks of resumed normal activity following cast removal (group R), or after 4 weeks of resumed activity supplemented with a daily treadmill‐walking task (group E). Immobilization resulted in a decrease in adductor longus muscle weight to 66.4% of control; total muscle end‐plate‐associated AChE was decreased to 51.4%. Total muscle ACh hydrolysis was not significantly affected. Mild daily exercise during recovery increased total muscle end‐plate AChE to control levels after 4 weeks, while in group R the corresponding level was significantly lower (84.4%). Decreased neuromuscular activity has different effects on end‐plate AChE and non‐end‐plate AChE. Mild endurance‐type overload during recovery from immobilization can accelerate recovery of end‐plate AChE activity to normal.