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Dual type of facilitation at the neuromuscular junction of the frog
Author(s) -
HortLegrand Claudine,
Metral Stéphane
Publication year - 1982
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880050504
Subject(s) - facilitation , neuromuscular junction , motor nerve , neuroscience , neural facilitation , shock (circulatory) , latency (audio) , audiology , psychology , biology , chemistry , physical medicine and rehabilitation , anatomy , medicine , communication , excitatory postsynaptic potential , telecommunications , inhibitory postsynaptic potential , computer science
End‐plate potentials were recorded intracellularly at the frog neuromuscular junction. Facilitation produced by conditioning shocks applied to the motor nerve was studied in two different ways: using either low‐frequency trains in Mg‐blocked preparations or using brief high‐frequency trains followed by a test shock of variable latency in D ‐tubocurarine‐blocked preparations. In both cases, two distinctly different types of motor end‐plates were observed. The first type showed a low quantum content and a marked facilitation without depression, while the second type showed a high quantum content, a poor facilitation, and a marked depression. The physiological significance of these findings is discussed.