Dual type of facilitation at the neuromuscular junction of the frog | Zendy

HortLegrand Claudine | Zendy; Metral Stéphane | Zendy

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Dual type of facilitation at the neuromuscular junction of the frog

Author(s) -

HortLegrand Claudine,

Metral Stéphane

Publication year - 1982

Publication title -

muscle and nerve

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.025

H-Index - 145

eISSN - 1097-4598

pISSN - 0148-639X

DOI - 10.1002/mus.880050504

Subject(s) - facilitation , neuromuscular junction , motor nerve , neuroscience , neural facilitation , shock (circulatory) , latency (audio) , audiology , psychology , biology , chemistry , physical medicine and rehabilitation , anatomy , medicine , communication , excitatory postsynaptic potential , telecommunications , inhibitory postsynaptic potential , computer science

End‐plate potentials were recorded intracellularly at the frog neuromuscular junction. Facilitation produced by conditioning shocks applied to the motor nerve was studied in two different ways: using either low‐frequency trains in Mg‐blocked preparations or using brief high‐frequency trains followed by a test shock of variable latency in D ‐tubocurarine‐blocked preparations. In both cases, two distinctly different types of motor end‐plates were observed. The first type showed a low quantum content and a marked facilitation without depression, while the second type showed a high quantum content, a poor facilitation, and a marked depression. The physiological significance of these findings is discussed.

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