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Signs of reinnervation in myasthenia gravis
Author(s) -
HiltonBrown Per,
Stålberg Erik V.,
Osterman Per Olof
Publication year - 1982
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880050307
Subject(s) - myasthenia gravis , reinnervation , cholinesterase , electromyography , medicine , motor unit , neuromuscular disease , anesthesia , surgery , disease , anatomy , physical medicine and rehabilitation
In a study of 71 patients with myasthenia gravis, the local fiber density of muscle fibers within motor units was estimated with single fiber electromyography (SFEMG). The fiber density was increased significantly in the patient group, compared to normal controls. This increase was not correlated to disease severity or duration, but was significantly higher in patients treated with cholinesterase inhibitors as compared to untreated patients. The study indicates a slight reorganization of the motor unit in untreated patients with myasthenia gravis and more pronounced changes in patients treated with cholinesterase inhibitors.