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Perineuritis in mononeuritis multiplex with cryoglobulinemia
Author(s) -
Konishi Tetsuro,
Saida Kyoko,
Ohnishi Akio,
Nishitani Hiroshi
Publication year - 1982
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880050216
Subject(s) - mononeuritis multiplex , perineurium , medicine , cryoglobulin , epineurium , cryoglobulinemia , endoneurium , nerve biopsy , pathology , sural nerve , vasculitis , peripheral neuropathy , immunology , anatomy , peripheral nerve , endocrinology , disease , hepatitis c virus , virus , diabetes mellitus
A case with mononeuritis multiplex associated with mixed cryoglobulinemia and mild persistent hepatitis is reported. Sural nerve biopsy specimens revealed thickening of the perineurium and vascular alterations with inflammatory cells infiltrating into the perineurium as well as the epineurium and endoneurium, thus having the features of perineuritis. Most myelinated and unmyelinated nerve fibers were lost. A therapeutic trial of corticosteroids decreased the serum titer of cryoglobulin without any improvement of clinical features.