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Histochemical staining of the acetylcholine receptor, acetylcholinesterase, and the axon terminal
Author(s) -
Bjornskov Elizabeth K.,
Norris Forbes H.,
MowerKuby Janis
Publication year - 1982
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880050211
Subject(s) - acetylcholinesterase , acetylcholine receptor , amyotrophic lateral sclerosis , neuromuscular junction , acetylcholine , axon , bungarotoxin , axon terminal , cholinesterase , chemistry , myasthenia gravis , stain , staining , neuroscience , receptor , anatomy , biology , endocrinology , medicine , biochemistry , pathology , enzyme , disease
Fluoresceinated alpha‐bungarotoxin (α‐BT) and the Pestronk‐Drachman neuromuscular stain were combined to demonstrate the acetylcholine receptor, the junctional acetylcholinesterase, and the nerve terminal on the same endplate. The method is reliable and rapid. Synapses in both normal muscle and muscle affected by amyotrophic lateral sclerosis (ALS) are equally well displayed.