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Neuron specific in vitro cytotoxicity of sera from patients with amyotrophic lateral sclerosis
Author(s) -
Roisen Fred J.,
Bartfeld Harry,
Donnenfeld Hyman,
Baxter Janet
Publication year - 1982
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880050109
Subject(s) - amyotrophic lateral sclerosis , toxicity , medicine , anterior horn cell , neuron , in vitro , cytotoxicity , cytotoxic t cell , motor neuron , immunology , pathology , neuroscience , biology , disease , genetics
Abstract Sera from patients with amyotrophic lateral sclerosis (ALS) were assayed for a neuron‐specific cytotoxic effect on long‐term organized cultures of neonatal mouse anterior horn segments. Blind studies show that ALS sera when incorporated into the culture media have a greater degree of antineuronal toxicity than sera from patients with other neurological diseases or from family members of ALS patients.