Chronic tetanus: Clinical report and histochemistry of muscle | Zendy

Risk Winthrop S. | Zendy; Bosch E. Peter | Zendy; Kimura Jun | Zendy; Cancilla Pasquale A. | Zendy; Fischbeck Kenneth H. | Zendy; Layzer Robert B. | Zendy

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Chronic tetanus: Clinical report and histochemistry of muscle

Author(s) -

Risk Winthrop S.,

Bosch E. Peter,

Kimura Jun,

Cancilla Pasquale A.,

Fischbeck Kenneth H.,

Layzer Robert B.

Publication year - 1981

Publication title -

muscle and nerve

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.025

H-Index - 145

eISSN - 1097-4598

pISSN - 0148-639X

DOI - 10.1002/mus.880040502

Subject(s) - tetanus , reinnervation , medicine , denervation , atrophy , masseter muscle , electromyography , muscle atrophy , muscle biopsy , tetanus antitoxin , neuromuscular junction , biopsy , pathology , anesthesia , anatomy , vaccination , biology , neuroscience , physical medicine and rehabilitation

A patient who was partially immune to tetanus developed nonfulminant tetanus after a minor injury. Manifestations of the disease persisted for over 17 months. Electrophysiologic studies revealed an absent silent period in the masseter muscle, large‐amplitude F‐responses, and denervation. A muscle biopsy showed neurogenic atrophy with reinnervation. This observation supports the existence of chronic tetanus and provides morphologic evidence for a peripheral action of tetanus toxin in humans.

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