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Duchenne muscular dystrophy: Unusual activation of single fibers in vitro
Author(s) -
Takagi Akio,
aka Ikuya
Publication year - 1981
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880040104
Subject(s) - duchenne muscular dystrophy , endoplasmic reticulum , muscular dystrophy , muscle biopsy , calcium , regeneration (biology) , biopsy , in vitro , chemistry , anatomy , myocyte , mdx mouse , medicine , pathology , biology , endocrinology , microbiology and biotechnology , biochemistry , dystrophin
Single skinned fibers were prepared from muscle biopsies of patients with Duchenne muscular dystrophy (DMD) and other neuromuscular diseases. The activation of the contractile system by calcium or strontium ion and the function of the sarcoplasmic reticulum were studied. In many fibers of the biopsy specimens from patients with DMD, activation by strontium revealed a pattern intermediate between those shown by the usual type 1 and type 2 fibers. These fibers were generally of smaller diameter and produced less maximal tension than type 1 and 2 fibers. The study of muscle of newborn animals suggests that this unusual pattern of activation might reflect either arrested development or incomplete regeneration after muscle necrosis in the disease.