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Polymyositis—an immunofluorescence study on the distribution of collagen types
Author(s) -
Duance Victor C.,
Black Carol M.,
Dubowitz Victor,
Hughes Graham R. V.,
Bailey Allen J.
Publication year - 1980
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880030605
Subject(s) - polymyositis , basement membrane , pathology , type iv collagen , immunofluorescence , antibody , staining , immunohistochemistry , laminin , chemistry , microbiology and biotechnology , medicine , biology , extracellular matrix , immunology , biochemistry
Type‐specific antibodies to the polymorphic types of collagen have been used to study their distribution in polymyositis. Dramatic increases were observed in the staining with antibodies to Type III collagen and, to a lesser extent, with antibodies to Types I, IV, and V. The changes in capillary and endomysial basement membrane collagens (Types IV and V) as well as the proliferation of perimysial Type III collagen are discussed in relation to the muscle atrophy observed during the disease.