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Spinal transection and the postnatal differentiation of slow myosin isoenzymes
Author(s) -
Margreth A.,
Libera L. Dalla,
Salviati G.,
Ischia N.
Publication year - 1980
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880030604
Subject(s) - myosin , cordotomy , anatomy , soleus muscle , population , hindlimb , chemistry , extensor digitorum muscle , spinal cord , biology , medicine , skeletal muscle , neuroscience , biochemistry , environmental health
Newborn rats underwent cordotomy, and the myosin composition of individual muscles was investigated 3 months postoperatively. The results indicate that, after cordotomy, the myosin composition in the extensor digitorum longus and tibialis anterior muscles is normal, whereas in the soleus muscle the myosin has catalytic and molecular properties intermediate between those of adult fast and slow myosin. Together with histochemical data these results indicate that spinal transection causes a developmental arrest in the soleus muscle, at a stage corresponding to a mixed fiber population.