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Carnitine levels in normal children and adults and in patients with diseased muscle
Author(s) -
Carrier Henri N.,
Berthillier Gisèle
Publication year - 1980
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880030409
Subject(s) - carnitine , myopathy , medicine , excretion , duchenne muscular dystrophy , muscular dystrophy , endocrinology , urinary system , physiology , skeletal muscle
An assay for evaluating carnitine levels in normal children and adults is described. After a 12‐hour period of fasting, individual variations in 24‐hour urinary excretion of carnitine were observed in adults. In children, there was a significant decrease in excretion from the 10th month to the third year, and then an increase until the 10th year. There was no significant difference between children and adults in the serum and skeletal muscle levels. Muscle carnitine levels were also studied in 12 cases of lipid‐storage myopathy and in cases of other muscle diseases, including Duchenne muscular dystrophy in children.

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