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Application of the freeze fracture technique to the study of human neuromuscular disease
Author(s) -
Schotland Donald L.,
Bonilla Eduardo
Publication year - 1980
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880030104
Subject(s) - neuromuscular disease , duchenne muscular dystrophy , muscular dystrophy , medicine , skeletal muscle , neuromuscular junction , disease , fracture (geology) , physical medicine and rehabilitation , anatomy , neuroscience , biology , paleontology
This is a review of the application of the freeze fracture technique to the study of human neuromuscular disease. The advantages and limitations of the method are discussed, and the application of the technique is illustrated by a study of skeletal muscle plasma membrane in Duchenne muscular dystrophy.