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Chloroquine‐induced cytosomes with curvilinear profiles in muscle
Author(s) -
Neville Hans E.,
MaunderSewry Caroline A.,
McDougall Jennifer,
Sewell John R.,
Dubowitz Victor
Publication year - 1979
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880020509
Subject(s) - chloroquine , medicine , disease , muscle weakness , weakness , muscle disease , immunology , surgery , malaria
Abstract A patient with systemic lupus erythematosus (SLE) was treated with chloroquine therapy for four years after the onset of her illness. Nine years after cessation of chloroquine, muscle weakness developed as part of the SLE. Four muscle biopsies performed for diagnostic purposes revealed varying degrees of inflammatory change as well as distinctive cytosomes with curvilinear profiles (CCPs). These CCPs were identical to those reported in Batten disease, a degenerative disorder of children which has a clinical course different from SLE. The CCPs seen in this case of SLE are thought to result from the effect of chloroquine on membrane systems within muscle cells. This report calls attention to the fact that CCPs are not unique to Batten disease but may also occur in muscle of SLE patients treated with chloroquine.