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Fatty acid biosynthesis in wallerian degeneration of rat sciatic nerve
Author(s) -
Koeppen Arnulf H.,
Papandrea John D.,
Mitzen Edward J.
Publication year - 1979
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880020508
Subject(s) - wallerian degeneration , sciatic nerve , palmitic acid , biosynthesis , fatty acid , degeneration (medical) , chemistry , biochemistry , medicine , endocrinology , biology , anatomy , enzyme , pathology
In‐vitro fatty acid biosynthesis was studied in normal rat sciatic nerve and during wallerian degeneration. Normal nerve incorporated 1,3‐C 14 ‐malonyl‐CoA and 1‐C 14 ‐acetyl‐CoA into fatty acids by a de‐novo biosynthetic pathway. The reaction product with highest radioactivity was palmitic acid, and the free fatty acids of nerve contained 90% of the total fatty acid label. During wallerian degeneration, there was a rapid increase of fatty acid biosynthesis that reached a peak between 16 and 24 days after nerve section. Values declined to normal levels at approximately 50 days.