Premium
Experimental myotonia induced in denervated muscles by 2,4‐D
Author(s) -
Eberstein Arthur,
Goodgold Joseph
Publication year - 1979
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880020507
Subject(s) - denervation , myotonia , isotonic , limiting , compound muscle action potential , anatomy , chemistry , medicine , hindlimb , anesthesia , electromyography , endocrinology , electrophysiology , myotonic dystrophy , physical medicine and rehabilitation , mechanical engineering , engineering
Rats were denervated in one hind limb and injected with 2,4‐dichlorophenoxyacetic acid (2,4‐D). Isotonic tetanic contractions of the muscles treated with 2,4‐D after more than 10 days of denervation revealed prolonged relaxation times similar to those of the intact side and characteristic of clinical myotonia. No myotonic discharges were observed in the muscles denervated for more than 10 days and treated with 2,4‐D. The increase in threshold for action potential generation secondary to denervation is suggested as the factor limiting the initiation of the repetitive discharges.