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Reinnervation of rat extensor digitorum longus muscles after free grafting
Author(s) -
Carlson Bruce M.,
Wagner Kenneth R.,
Max Stephen R.
Publication year - 1979
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880020411
Subject(s) - reinnervation , choline acetyltransferase , anatomy , extensor digitorum longus muscle , medicine , extensor digitorum muscle , neuromuscular junction , biology , acetylcholine , endocrinology , neuroscience , skeletal muscle , soleus muscle
Free grafts of the extensor digitorum longus (EDL) muscle of the rat are invaded by regenerating nerve fibers during the second postoperative week. Neuromuscular junctions are established during the third week. Levels of choline acetyltransferase (CAT) activity parallel the invasion of the graft by nerve fibers, but this activity never returns to control levels. We conclude that incomplete reinnervation of free muscle grafts may be a factor in the failure of such grafts to reattain the mass of control muscles.